cangrelor class

cangrelor class


What drug class is cangrelor?

Kengreal is a prescription medicine used as an adjunct to Percutaneous Coronary Intervention. Kengreal may be used alone or with other medications. Kengreal belongs to a class of drugs called Antiplatelet Agents, Cardiovascular.

Is cangrelor an antiplatelet?

Cangrelor has a linear dose-dependent pharmacokinetic profile that leads to stable antiplatelet effects. Platelet inhibition is rapid and potent, occurring within minutes.

Is cangrelor an ADP inhibitor?

Cangrelor is a reversible, potent, competitive inhibitor of the ADP P2Y(12) receptor that is administered intravenously and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.

What is the other name for cangrelor?

Cangrelor, sold under the brand name Kengreal in the United States, CANREAL in India ( MSN Labs ) and Kengrexal in the European Union) is a P2Y12 inhibitor FDA approved as of June 2015 as an antiplatelet drug for intravenous application.

Is cangrelor an anticoagulant?

Cangrelor is a potent, rapid-acting, reversible antagonist of the P2Y12 receptor approved by the United States Food and Drug Administration in 2015 as an intravenous anticoagulant [13]. Therapeutic dosage of cangrelor achieves platelet inhibition up to 95% within 2 min of its administration.

How much does cangrelor cost?

The standard dosage to treat one patient undergoing percutaneous coronary intervention (PCI) with cangrelor (Kengreal) will have a wholesale acquisition cost of $749, Raymond Russo, senior vice president of The Medicines Company, said at a June 23 press briefing.

Why is cangrelor used?

Cangrelor injection is used in patients undergoing percutaneous coronary intervention (PCI) to lower the risk of blood clots and heart attack.

Is cangrelor a prodrug?

Therapeutic doses of cangrelor achieve platelet inhibition greater than 90% to 95%. Unlike other P2Y12 receptor antagonists (eg, ticlopidine, clopidogrel, ticagrelor, prasugrel), cangrelor is not a prodrug and d
Is tirofiban an anticoagulant?

Serious - Use Alternative (1)tirofiban and apixaban both increase anticoagulation.

What is IV cangrelor?

Cangrelor is a relatively new antiplatelet drug that has been approved for use as an adjunct therapy to percutaneous coronary intervention (PCI) to decrease peri-procedural myocardial infarction (MI), coronary revascularization, and stent thrombosis.

What is the mode of action of ticagrelor?

Mechanism of Action and Chemical Properties

Ticagrelor is an orally administered direct-acting P2Y12-receptor antagonist. In vitro studies have demonstrated that ticagrelor binds reversibly and noncompetitively to the P2Y12 receptor at a site distinct from that of the endogenous agonist adenosine diphosphate (ADP).

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